Discovering Treatments & Cures Through Innovative Translational Research

The physician-scientists and basic researchers in the surgical oncology research laboratory, under the leadership of Robert S. Warren, M.D., are conducting research aimed at identifying lesions that lead to the development and spread of cancer.



Recent Publications

Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.
Genes & development, Sep-15-2009; 2318: 2152-65
Satpathy M, Shao M, Emerson R, Donner DB, Matei D
Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity.
The Journal of biological chemistry, Jun-05-2009; 28423: 15390-9.  Epub 2009 Mar 26.
Bertagnolli MM, Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Warren RS, Redston M
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Apr-10-2009; 2711: 1814-21.  Epub 2009 Mar 9.
Bertagnolli MM, Warren RS, Niedzwiecki D, Mueller E, Compton CC, Redston M, Hall M, Hahn HP, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Loda M
p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
Clinical cancer research : an official journal of the American Association for Cancer Research, Mar-15-2009; 156: 2116-22.  Epub 2009 Mar 10.
Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK
Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
Endocrine-related cancer, Mar-01-2009; 161: 267-79.  Epub 2008 Nov 5.
Pincheira R, Baerwald M, Dunbar JD, Donner DB
Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
The EMBO journal, Feb-04-2009; 283: 261-73.  Epub 2009 Jan 08.
Ruan DT, Warren RS, Moalem J, Chung KW, Griffin AC, Shen W, Duh QY, Nakakura E, Donner DB, Khanafshar E, Weng J, Clark OH, Kebebew E
Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers.
Surgery, Dec-01-2008; 1446: 908-13; discussion 913-4.
Pincheira R, Donner DB
The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons.
Annals of the New York Academy of Sciences, Nov-01-2008; 1144: 53-5.
Pincheira R, Castro AF, Ozes ON, Idumalla PS, Donner DB
Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.
Journal of immunology (Baltimore, Md. : 1950), Jul-15-2008; 1812: 1288-98.
Chan JA, Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Thomas J, Schaefer P, Whittom R, Hantel A, Goldberg RM, Warren RS, Bertagnolli M, Fuchs CS
Association of family history with cancer recurrence and survival among patients with stage III colon cancer.
JAMA : the journal of the American Medical Association, Jun-04-2008; 29921: 2515-23.
Horvai AE, Schaefer JT, Nakakura EK, O'Donnell RJ
Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, May-01-2008; 215: 517-24.  Epub 2008 Jan 18.
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